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pygsl
A Python interface for the GNU scientific library. [Open Source, GPL/LGPL]

PyGiNaC
A Python interface to the C++ library GiNaC (an open framework for symbolic computation within the C++ programming language). [Open Source, LGPL]

NumPy
Numerical Python adds a fast, compact multidimensional array language facility to Python. [Open Source, Python license]

QuantLib
A free/open-source library for quantitative finance. [Open Source, BSD-like]

R/SPlus
Python interface to the R system for statistical computing and graphics. [Open Source, BSD-like]

SciPy
Open Source Library of Scientific Tools. SciPy supplements the popular Numeric module, gathering a variety of high level science and engineering modules together as a single package. Within SciPy are modules for graphics and plotting, optimization, integration, special functions, signal and image processing, genetic algorithms, ODE solvers, and others. [Open Source, BSD-like]

GMPY
Provides multiprecision arithmetic functionality to Python programmers. [Open Source, LGPL]

ScientificPython
A collection of Python modules that are useful for scientific computing. [Open Source, LGPL]

Cost Accounting Module
Python code module containing financial calculation functions for industrial cost analysis.

Gary Strangman's Python Modules
Statistical functions. [Open Source/GPL]